Clinical and in vitro resistance to bexarotene in adult T-cell leukemia: loss of RXR-α receptor
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چکیده
منابع مشابه
Clinical and in vitro resistance to bexarotene in adult T-cell leukemia: loss of RXR- receptor
The oral rexinoid bexarotene (Targretin) is widely used for treatment of cutaneous T-cell lymphomas (CTCL). We recently reported the first case of adult T-cell leukemia/lymphoma (ATLL) that responded rapidly to combination therapy of bexarotene and interferon (IFN)2b with complete clinical response. We demonstrated that bexarotene induced apoptosis of the patient’s malignant peripheral blood T-...
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ژورنال
عنوان ژورنال: Blood
سال: 2008
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2008-03-141424